Exploratory or untargeted ultra performance liquid chromatography–mass spectrometry
(UPLC–MS) profiling offers an overview of the complex lipid species diversity present in …

Lipidomics is a critical part of metabolomics and aims to study all the lipids within a living
system. We present here the development and evaluation of a sensitive capillary UPLC-MS …

Liquid chromatography–mass spectrometry (LC–MS) methods are most often used for
untargeted metabolomics and lipidomics. However, methods have not been standardized as …

Lipid coverage is crucial in comprehensive lipidomics studies challenged by high diversity in
lipid structures and wide dynamic range in lipid levels. Current state-of-the-art lipidomics …

In order to profile the lipidome for untargeted lipidomics applications, analysis by ultra-high
performance liquid chromatography–high resolution mass spectrometry (UHPLC-HRMS) …

A key element of successful lipidomics analysis is a sufficient extraction of lipid molecules
typically by two-phase systems such as chloroform-based Bligh and Dyer (B&D). However …

Lipidomic approaches are now widely used to investigate the relationship between lipid
metabolism, health and disease. Large-scale lipidomics studies typically aim to quantify …

The goal of untargeted lipidomics is to have high throughput, yet comprehensive and
unambiguous identification and quantification of lipids. Novel stationary phases in LC …

In the past decade, various lipidomics methodologies have been developed using mass
spectrometry based analytical technologies, enabling wide coverage lipid detection in a …

Reversed-phase ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–
MS) is the method of choice for lipidomic profiling of blood plasma. For comprehensive …