Since the resident cardiac stem/progenitor cells were discovered, their ability to maintain the
architecture and functional integrity of adult heart has been broadly explored. The methods …

Cardiac resident stem/progenitor cells are critical to the cellular and functional integrity of the
heart by maintaining myocardial cell homeostasis. Given their central role in myocardial …

Resident cardiac stem cells (CSCs) are characterized by their capacity to self-renew in
culture, and are multipotent for forming normal cell types in hearts. CSCs were originally …

Background Side-population (SP) cells, identified by their capacity to efflux Hoechst dye, are
highly enriched for stem/progenitor cell activity. They are found in many mammalian tissues …

BACKGROUND: Side population cells are a rare subset of cells found in the adult heart that
are highly enriched for stem and progenitor cell activity. Recent studies have suggested that …

Abstract Aims Cardiac progenitor cells (CPCs) have been isolated from adult and
developing hearts using an anti-mouse Sca-1 antibody. However, the absence of a human …

Heart failure remains a leading cause of morbidity and mortality. The cellular mechanism
underlying the development of cardiac dysfunction is a decrease in the number of viable …

Methods and Results The cardiac stem/progenitor cells from adult mice were seeded at low
density in serum-free medium. The colonies thus obtained were expanded separately and …

Background Myocardial infarction remains the leading cause of mortality in developed
countries despite recent advances in its prevention and treatment. Regenerative therapies …

Side population (SP) cells, which can be identified by their ability to exclude Hoechst 33342
dye, are one of the candidates for somatic stem cells. Although bone marrow SP cells are …