Observational studies suggest that high homocysteine levels are a risk factor for brain
atrophy and Alzheimer disease, but intervention studies have been inconclusive. New …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

There is some evidence from recent observational studies that hyperhomocysteinemia is a
risk factor for cognitive dysfunction, including Alzheimer's disease and vascular dementia …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Context Blood levels of homocysteine may be increased in Alzheimer disease (AD) and
hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct …

BACKGROUND: Prospective cohort studies have not been consistent in showing an
association between serum homocysteine and dementia. OBJECTIVE: To conduct a meta …

Diseases of the central nervous system are found in patients with severe
hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, dose-dependent …

Few B-vitamin trials to lower homocysteine (Hcy) have reported evidence of beneficial
effects on cognition in older adults with cognitive impairment or Alzheimer's disease. This …

Background An increased rate of brain atrophy is often observed in older subjects, in
particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain …

Objective: To explore the association between high homocysteine levels and risk of
Alzheimer disease (AD) in the Washington Heights-Inwood Columbia Aging Project …