Although the formation of 30-nm chromatin fibers is thought to be the most basic event of
chromatin compaction, it remains controversial because high-resolution imaging of …

How is a long strand of genomic DNA packaged into a mitotic chromosome or nucleus? The
nucleosome fiber (beads-on-a-string), in which DNA is wrapped around core histones, has …

Cryoelectron microscopy of vitrified sections has become a powerful tool for investigating the
fine structural features of cellular compartments. In the present study, this approach has …

According to the folded fibre model, chromosomes are composed of long fibres which are
arranged in apparently irregular, or high entropy, configurations. During interphase these …

A long strand of DNA is wrapped around the core histone and forms a nucleosome.
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

Chromatin fibers have been observed and measured in frozen hydrated sections of three
types of cell (chicken erythrocytes and sperm of Patiria miniata and Thyone briareus) …

Diffraction of x-rays from living cells, isolated nuclei, and metaphase chromosomes gives
rise to several major low angle reflections characteristic of a highly conserved pattern of …

We have adapted the fluorescencein situhybridization technique to single-cell gel
electrophoresis (comet assayed) preparations. Since cells were embedded in agarose …

We have developed procedures for depositing intact mitotic chromosomes and isolated
residual scaffolds on electron microscope grids at controlled and reproducible levels of …