Current progress in anticalcif ication for bioprosthetic and polymeric heart valves

NR Vyavahare, W Chen, RR Joshi, CH Lee… - Cardiovascular …, 1997 - Elsevier
The use of bioprosthetic valves fabricated from fixed heterograft tissue (porcine aortic valves
or bovine pericardium) in heart valve replacement surgery is limited because of calcification …

Prevention of calcification of bioprosthetic heart valve leaflets by Ca2+ diphosphonate pretreatment

TP Johnston, FJ Schoen, RJ Levy - Journal of pharmaceutical …, 1988 - Wiley Online Library
Calcification frequently causes failure of bioprosthetic heart valves (BHV) fabricated from
glutaraldehyde‐pretreated porcine aortic valve or bovine pericardium. Systemic …

Anticalcification treatments of bioprosthetic heart valves: in vivo studies in sheep

M JONES, EE EIDBO, SL HILBERT… - Journal of Cardiac …, 1989 - Wiley Online Library
Studies performed by other investigators have shown that a number of preimplantation
processes inhibit the calcification of pieces of porcine aortic valves and of bovine parietal …

Prevention of bioprosthetic heart valve calcification: strategies and outcomes

LP Bre, R McCarthy, W Wang - Current Medicinal Chemistry, 2014 - ingentaconnect.com
Despite the significant advances in cardiac surgery, heart valve replacement still faces a
dilemma. While mechanical valves offer lifelong durability they also commit patients to …

[PDF][PDF] Bioprosthetic heart valve calcification: membrane-mediated events and alkaline phosphatase

FJ Schoen, RJ Levy - 1992 - deepblue.lib.umich.edu
Calcification-induced stenosis or tearing is the principal cause of failure of clinical heart
valve bioprostheses fabricated from glutaraldehyde-pretreated porcine aortic valves and …

Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate

HS Rapoport, JM Connolly, J Fulmer, N Dai, BH Murti… - Biomaterials, 2007 - Elsevier
Heart valve replacements fabricated from glutaraldehyde (Glut)-crosslinked heterograft
materials, porcine aortic valves or bovine pericardium, have been widely used in cardiac …

Calcification of tissue heart valve substitutes: progress toward understanding and prevention

FJ Schoen, RJ Levy - The Annals of thoracic surgery, 2005 - Elsevier
Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies

G Golomb, R Langer, FJ Schoen, MS Smith… - Journal of controlled …, 1986 - Elsevier
Calcification is the Principal cause of the clinical faliure of bioprosthetic heart valves (BHV)
fabricated from glutaraldehy de-treated porcine valves or bovine pericardium. This study …

Heart valve bioprostheses: antimineralization

FJ Schoen, RJ Levy - European journal of cardio-thoracic …, 1992 - academic.oup.com
Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Controlled release of diphosphonates from synthetic polymers to inhibit calcification

G Golomb - Journal of biomaterials applications, 1987 - journals.sagepub.com
Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated
from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and …