By virtue of their large number, widespread distribution and important roles in cell
physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

Among the different families of transmembrane receptors, G-proteincoupled receptors
(GPCR) form the largest superfamily being present in yeast, plants, protozoa and metazoa …

G protein–coupled receptors (GPCRs) respond to a chemically diverse plethora of signal
transduction molecules. The notion that GPCRs also signal without an external chemical …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

During the past 10 years or so, associated with the introduction of molecular biology
techniques to G protein coupled receptor (GPCR) research, outstanding progress has been …

G protein-coupled receptors (GPCRs) represent a major class of proteins in the genome of
many species, including humans. In addition to the mapping of a number of human …

Activating and inactivating mutations in numerous human G protein-coupled receptors
(GPCRs) are associated with a wide range of disease phenotypes. Here we use several …

G protein coupled-receptors (GPCRs) have been proven to be the most successful class of
druggable targets in the human genome. In fact, 30–50% of marketed drugs are estimated to …

Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for
drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR …