Substitution of calorie restriction for protective effects of estrogen on cardiometabolic risk factors and oxidative stress in obese postmenopausal rat model

Z Hajializadeh, M Khaksari, H Najafipour, M Sanjari… - Life Sciences, 2022 - Elsevier
Estrogen has an anti-obesity effect and plays an important role in improving cardiometabolic
disorders. Weight loss and reduction in calorie intake impede the development of obesity …

Protective effects of calorie restriction and 17-β estradiol on cardiac hypertrophy in ovariectomized obese rats

Z Hajializadeh, M Khaksari, S Dabiri… - Plos one, 2023 - journals.plos.org
Obesity and menopause lead to cardiovascular diseases. Calorie restriction (CR) can
modulate estrogen deficiency and obesity-related cardiovascular diseases. The protective …

Metabolic effects of estrogen substitution in combination with targeted exercise training on the therapy of obesity in ovariectomized Wistar rats

N Zoth, C Weigt, S Zengin, O Selder, N Selke… - The Journal of steroid …, 2012 - Elsevier
Postmenopausal women tend to have a higher risk in developing obesity and thus metabolic
syndrome. Recently we could demonstrate that physical activity and estrogen replacement …

Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats

S Sivasinprasasn, P Sa-Nguanmoo, W Pratchayasakul… - Age, 2015 - Springer
Women have a lower incidence of cardiovascular diseases (CVD) than men at a similar age
but have an increased incidence of CVD and metabolic syndrome after menopause …

Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance

RE Stubbins, K Najjar, VB Holcomb… - Diabetes, Obesity …, 2012 - Wiley Online Library
Aims: Obesity is associated with insulin resistance, liver steatosis and low‐grade
inflammation. The role of oestrogen in sex differences in the above co‐morbidities is not fully …

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

JPG Camporez, FR Jornayvaz, HY Lee, S Kanda… - …, 2013 - academic.oup.com
Estrogen replacement therapy reduces the incidence of type 2 diabetes in postmenopausal
women; however, the mechanism is unknown. Therefore, the aim of this study was to …

Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in …

HA Hassan, MA Abdel-Wahhab - Journal of physiology and biochemistry, 2012 - Springer
The aim of the present study was to investigate the cardiac biomarker changes in
experimental bilateral ovariectomized (OVX) rats in addition to evaluating the role of …

Treatment with 17β-estradiol reduced body weight and the risk of cardiovascular disease in a high-fat diet-induced animal model of obesity

WJ Ting, CY Huang, CH Jiang, YM Lin… - International journal of …, 2017 - mdpi.com
Estrogen receptor α (ERα) and estrogen receptor β (ERβ) play important roles in
cardiovascular disease (CVD) prevention. Recently, these estrogen receptors were …

Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female …

JW Xu, QL Xiang, GP Lin, XD Fu, KW Zhou… - Molecular biology …, 2012 - Springer
Metabolic syndrome (MBS), a cluster of metabolic abnormalities and visceral fat
accumulation, increases cardiovascular risks in postmenopausal women. In addition to …

[PDF][PDF] Effects of estrogen on insulin sensitivity and adipokines in mice

T Yuan, J Li, WG Zhao, Y Fu… - Acta Academiae …, 2015 - journal13.magtechjournal.com
Objective To study the potential mechanisms via which estrogen exerts its effects on the
insulin sensitivity in mice. Methods Totally 36 female C57BL/6J mice aged 6 weeks were …