The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

Tedisamil has been described as a selective inhibitor of a fast inactivating transient outward
current (i to, f) in rat ventricular myocytes. Because recent reports demonstrated the …

The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22°
C to study the transient outward current (I to) and its sensitivity to the antimycotics …

The use-dependent features of 4-aminopyridine-induced block of the transient outward
current were investigated under voltage clamp conditions in dog ventricular myocardial …

The mechanism of ajmaline-induced inhibition of the transient outward current (Ito) has been
investigated in right ventricular myocytes of rat using the whole cell patch clamp technique …

Abstract The effects of disopyramide (1–30 μM) on the 4-aminopyridine sensitive transient
outward current (I to), on the rapid component of the delayed rectifier potassium current (I Kr) …

In rat ventricular myocytes we found two components of transient outward current, which
could be discriminated time-and voltage-dependently. Besides the well known fastly …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

The effects of imipramine, a tricyclic antidepressant, on action potential characteristics and
plateau membrane currents were studied in isolated guineapig ventricular myocytes, using …

The blocking action of 4-aminopyridine (4-AP) on the transient outward K+ current (I TO) in
isolated rat ventricular myocytes was studied using the whole-cell configuration of the patch …