Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We
investigated the effect of oxygen tension on the formation and function of osteoclasts, the …

We investigated the effect of hypoxia on rat osteoblast function in long-term primary cultures.
Reduction of pO2 from 20% to 5% and 2% decreased formation of mineralized bone …

Active pathological bone destruction in humans often occurs in locations where oxygen
tension (pO2) is likely to be low, for example, at the sites of tumours, inflammation, infections …

Bone homeostasis is profoundly affected by local pH and oxygen tension. It has long been
recognised that the skeleton contains a large reserve of alkaline mineral (hydroxyapatite) …

Bone is a unique tissue in which to examine mechanotransduction due to its essential role in
weight bearing. Within bone, the osteocyte is an ideal cellular mechanotransducer …

To maintain normal cellular and physiological function, sufficient oxygen is required.
Recently, evidence has suggested that hypoxia, either pathological or environmental, may …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

We examined the effects of HCO3− and CO2 acidosis on osteoclast-mediated Ca2+ release
from 3-day cultures of neonatal mouse calvaria. Ca2+ release was minimal above pH 7.2 in …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Dental disease due to osteoclast (OC) overactivity reaches epidemic proportions in older
domestic cats and has also been reported in wild cats. Feline odontoclastic resorptive …