The influence of newly synthesized thiazole derivative N-(5-benzyl-1, 3-thiazol-2-yl)-3, 5-
dimethyl-1-benzofuran-2-carboxamide on cellular ultrastructure and antioxidant system …

Background. The influence in vitro of thiazole derivative 8-methyl-2-Me-7-[trifluoromethyl-
phenylmethyl]-pyrazolo-[4, 3-e]-[1, 3]-thiazolo-[3, 2-a]-pyrimidin-4 (2H)-one (PP2) on the …

Thiazole derivatives were shown to have toxic effects in vitro on cancer cells of different
origin and can be considered as potentially antineoplastic, but their effect on the normal …

Background. Previous studies have shown a pronounced cytotoxic effect of thiazole
derivatives in combination with polymeric carriers on tumor cells. At the same time, the …

Background. Many types of tumors are sensitive to changes in prooxidant-antioxidant
balance. Thus, further studies on reactive oxygen species inducing antitumor drugs that …

Novel and effective treatments are urgently needed for cancer, which is still the leading
cause of death in the world. Biological characteristics linked to thiazole derivatives span a …

Thiazole derivatives have cytotoxic effects towards tumor cells, such as glioblastoma,
melanoma, leukemia and lymphoma. However, the intracellular mechanism of this action is …

Background. A pronounced cytotoxic action of the thiazole derivatives complexed with
polymeric carriers on tumor cells in vitro was reported earlier, while no cytotoxicity of these …

Accepted: 20 March 2019 oxidative stress is one of the main mechanisms by which
anticancer chemotherapeutics damage normal tissues and organs. at the same time, it is an …

As a result of metabolic transformations of substances in the human body in the reactions of
lipid peroxidation, reactive oxygen species are formed. Normally, the regulation of the …