The use of imaging techniques has become an essential tool in cell biology. In particular,
advances in fluorescence microscopy and conventional transmission electron microscopy …

The microscope has been indispensable to the last century of chromatin structure research.
Microscopy techniques have revealed that the three-dimensional location of chromatin is not …

Advances in the specific fluorescent labeling of chromatin in fixed and living human cells in
combination with three-dimensional (3D) and 4D (space plus time) fluorescence microscopy …

Electron microscopy has been the 'gold standard'of spatial resolution for studying the
structure of the cell nucleus. Electron spectroscopic imaging (ESI) offers advantages over …

Despite over 30years of work, the fundamental structure of eukaryotic chromatin remains
controversial. Here, we review the roots of this controversy in disparities between results …

The cell nucleus is a highly compartmentalized structure. In this review we describe
controversial views on higher order chromatin organization from the level of higher order …

The organization of interphase chromatin spans many topics, ranging in scale from the
molecular level to the whole nucleus, and its study requires a concomitant range of …

The nuclear architecture is considered an important contributor to genome function.
Although the fine structural features of the cell nucleus have been investigated extensively …

In the recent years it has become clear that our genome is not randomly organized and its
architecture is tightly linked to its function. While genomic studies have given much insight …

Publisher Summary Nuclear DNA in eukaryotes has a nucleosomal organization. Specific
assemblies of nucleosomes and nonhistone nuclear proteins play important roles in local …