The putative Class III antiarrhythmic benzopyran compound terikalant (RP62719) has been
applied to isolated rat ventricular myocytes. The drug, at extracellular concentrations from 1 …

The cellular mechanism of action of terikalant, an investigational antiarrhythmic agent known
to block the inward rectifier and other potassium currents, has not yet been fully clarified. The …

The K+ channel blocking action of the class Ic antiarrhythmic agent flecainide was compared
with that of propafenone and quinidine in isolated adult rat ventricular myocytes by using the …

1. The effects of TYB-3823 (B-GYKI 38233), a new antiarrhythmic drug, were
electrophysiologically examined in the guinea-pig ventricular muscles. 2. TYB-3823 at …

A class III antiarrhythmic agent that preferentially increases the effective refractory period
without altering conduction velocity holds considerable promise for the treatment of life …

Ketanserin (KT), an antihypertensive agent, has been shown to prolong action potential
duration (APD) and QT interval and to induce torsade de pointes in some patients. We …

Effects of KT-362, a New Antiarrhythmic Agent, on Membrane Ionic Currents of Guinea Pig
Ventricular Myocytes Page 1 Vol. 270, No.3 Printed in USA ABSTRACT ABBREVIATIONS …

The potassium currents in rat and guinea pig ventricular myocytes and mouse astrocytes
were studied using tedisamil, a novel antiarrhythmic agent. A 1 to 20 microM dosage of …

The effects of N-(dicyclohexyl-carbamoylmethyl)-N-(3-diethylamino-propyl)-4-nitro-
benzamide hydrochloride (AWD 23-111), a novel antiarrhythmic compound, were studied in …

The actions of ambasilide (LU-47110) on the action potential and membrane currents of
isolated guinea pig ventricular myocytes were studied using voltage clamp techniques …