The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer's
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP
derivatives, β-amyloid (Aβ) peptides, and APP intracellular domain. Expression of the …

Amyloid precursor protein (APP), the parent molecule to amyloid β peptide, is part of a
larger gene family with two mammalian homologues, amyloid precursor-like protein 1 …

Abstract APP, APLP1, and APLP2 form a family of mammalian membrane proteins with
unknown function. APP, however, plays a key role in the molecular pathology of Alzheimer's …

The amyloid precursor protein (APP) involved in Alzheimer's disease is a member of a larger
gene family including amyloid precursor-like proteins APLP1 and APLP2. We generated and …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

The amyloid precursor protein (APP) is well known to be involved in the pathophysiology of
Alzheimer's disease (AD) via its cleavage product amyloid ß (Aß). However, the …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

The Alzheimer's amyloid precursor protein (APP) belongs to a conserved gene family that
also includes the mammalian APLP1 and APLP2, the Drosophila APPL, and the C. elegans …