Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents

SS Abd El-Karim, MM Anwar, NA Mohamed, T Nasr… - Bioorganic …, 2015 - Elsevier
This study deals with design and synthesis of novel benzofuran–pyrazole hybrids as
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …

Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents

W Xie, Y Wu, J Zhang, Q Mei, Y Zhang, N Zhu… - European Journal of …, 2018 - Elsevier
A hybrid pharmacophore approach was adopted to design and synthesize new series of
pyridone-thiazole hybrid compounds. The structures of the compounds were established by …

Novel 1, 2, 4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

HAM El-Sherief, BGM Youssif, SNA Bukhari… - Bioorganic …, 2018 - Elsevier
A series of novel compounds carrying 1, 2, 4-triazole scaffold was synthesized and
evaluated for their anticancer activity against a panel of cancer cell lines using MTT assay …

Design, synthesis, anticancer activity of new amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids: An insights from molecular docking, molecular …

N Gariganti, SK Loke, E Pagadala, P Chinta… - Journal of Molecular …, 2023 - Elsevier
A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …

Synthesis, cytotoxicity, and molecular properties prediction of novel 1, 3-diarylpyrazole derivatives

SN Baytas, N Inceler, A Yılmaz - Medicinal Chemistry Research, 2013 - Springer
A novel combinatorial library of ester and amide derivatives of 1, 3-diarylpyrazoles was
designed and synthesized. Anticancer activities of these compounds were assessed against …

A Click synthesis, molecular docking and biological evaluation of 1, 2, 3-triazoles-benzoxazepine hybrid as potential anticancer agents

M Ashram, AY Habashneh, S Bardaweel… - Medicinal Chemistry …, 2023 - Springer
Abstract A series of novel 1, 2, 3-triazole-benzoxazepine hybrid molecules were synthesized
and evaluated for their anticancer properties against four cancer cell lines (Caco-2, PC3 …

Synthesis, cytotoxicity of some pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action

EM Husseiny - Bioorganic Chemistry, 2020 - Elsevier
A novel series of pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety
were designed and synthesized. Chemical structures were confirmed by spectral data and …

Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents

EA Fayed, SI Eissa, AH Bayoumi, NA Gohar… - Molecular …, 2019 - Springer
Diamino-4-(3-trifluoromethylphenyldiazenyl)-1 H-pyrazole was used as a starting scaffold for
the synthesis of new pyrazole-based heterocycles to study their effects on the proliferation of …

New 1, 2, 4‐Triazole Scaffolds as Anticancer Agents: Synthesis, Biological Evaluation and Docking Studies

NK Maddali, VKV Ivaturi… - …, 2021 - Wiley Online Library
Abstract A series of novel 4, 5‐diphenyloxazol‐1, 2, 4‐triazole derivatives (6 a–6 l) were
synthesized and screened for anticancer activity against the prostate lung cancer cell lines …

Synthesis, antitumor activity, enzyme assay, DNA binding and molecular docking of Bis-Schiff bases of pyrazoles

NM Morsy, AS Hassan, TS Hafez, MRH Mahran… - Journal of the Iranian …, 2021 - Springer
A novel series of Bis-Schiff bases of pyrazoles 9–24 were synthesized by the direct
condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly …