According to the folded fibre model, chromosomes are composed of long fibres which are
arranged in apparently irregular, or high entropy, configurations. During interphase these …

Although the formation of 30-nm chromatin fibers is thought to be the most basic event of
chromatin compaction, it remains controversial because high-resolution imaging of …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

Each level of DNA folding in cells corresponds to a distinct chromatin structure. The basic
chromatin units, nucleosomes, are arranged into solenoids which form chromatin loops. To …

Thin sections of the testicular follicles of the grasshopper Laplatacris dispar were studied
under the electron microscope. In the primary spermatocytes, during meiotic prophase, three …

Electron microscopy of HeLa metaphase nucleoids (ie whole metaphase cells exposed to 2
M salt and non-ionic detergent) spread by the Kleinschmidt technique, reveals a variety of …

Chromosomes consist of single DNA‐histone fibres (with non‐histone protein and RNA in
the active regions) that are packed by folding or coiling into fibres which can be classified …

Interphase and metaphase chromosomes have been isolated by spreading unfixed cells on
the Langmuir trough, followed by critical point drying. Both types of chromosomes prove to …

Chromatin fibers must fold or coil in the process of chromosome condensation. Patterns of
coiling have been demonstrated for reconstituted chromatin, but the actual trajectories of …

Publisher Summary The electron micrographs of the cell nucleus and chromosomes provide
at first sight a confusing and not very informative picture. The reasons for this are not …