Senile plaques, a hallmark of Alzheimer's disease (AD), contain amyloid β-peptide (Aβ),
which is generated from the larger amyloid β protein precursor (APP). In addition to APP …

Amyloid precursor protein (APP), the parent molecule to amyloid β peptide, is part of a
larger gene family with two mammalian homologues, amyloid precursor-like protein 1 …

The amyloid precursor protein (APP) and its mammalian homologs, APLP 1, APLP 2, have
been allocated to an organellar pool residing in the Golgi apparatus and in endosomal …

Although abnormal processing of amyloid precursor protein (APP) leads to early onset of
Alzheimer's disease, the normal function of this protein is poorly understood. APP is widely …

Amyloid precursor proteins (APPs) are evolutionary conserved from nematodes to man
(Jacobsen and Iverfeldt in Cell Mol Life Sci 66: 2299–2318, 2009) suggesting an important …

Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning
glycoprotein which is endoproteolytically processed to Aβ, a 39–43 amino acid peptide that …

The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer's
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …

The Alzheimer's disease (AD) β-amyloid precursor protein (APP) and the amyloid precursor-
like protein 1 (APLP1) and 2 (APLP2) are members of a superfamily of proteins that appear …

The amyloid precursor protein (APP) involved in Alzheimer's disease is a member of a larger
gene family including amyloid precursor-like proteins APLP1 and APLP2. We generated and …

The Drosophila Appl gene encodes a transmembrane protein that is expressed exclusively
in neurons. Amino acid comparisons show that APPL protein is a member of the amyloid …