The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a
series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting …

We report here the synthesis and binding studies of oligo-2 '-deoxyribonucleotides (ODNs)
containing 2 '-deoxyuridines, modified at the 5-position by linkers ending with either one or …

Oligonucleotides incorporating the 7‐propynyl derivatives of 8‐aza‐7‐deaza‐2′‐
deoxyguanosine (3b) and 8‐aza‐7‐deaza‐2′‐deoxyadenosine (4b) were synthesized and …

We report the properties of hydrophobic isosteres of pyrimidines and purines in synthetic
DNA duplexes. Phenyl nucleosides 1 and 2 are nonpolar isosteres of the natural thymidine …

Base-modified nucleotide residues have been appended to the 5′-terminus of the self-
complementary oligo-2′-deoxynucleotide duplex [5′-d (CGCGCG)] 2 as dangling ends …

Noncovalent interactions between aromatic molecules are widely believed to be important
contributing factors in the stabilization of organized structure in biological macromolecules …

We have prepared triplex-forming oligonucleotides containing the nucleotide analogue 5-
dimethylaminopropargyl deoxyuridine (DMAPdU) in place of thymidine and examined their …

Novel deoxyadenosine derivatives tethering a phenyl or naphthyl group by means of an
amido linker have been synthesized, and these derivatives, stacking on the 5 'end of a DNA …

The addition of the propynyl group at the 5 position of pyrimidine nucleotides is highly
stabilising. We have determined the thermodynamic stability of the DNA· RNA hybrid r …

The efficiency of chemical ligation method have been demonstrated by assembling a
number of DNA duplexes with modified sugar phosphate backbone. Condensation on a …