The modes in which quinidine blocks the delayed K current (1K) of rabbit sinoatrial and
atrioventricular nodes were investigated by voltage clamp experiments using small …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

The interaction of quinidine with a cloned human cardiac potassium channel (HK2)
expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage …

The antiarrhythmic drug quinidine has been shown to block several types of K+ channel
currents in cardiac preparations including the transient outward current (Ito). To characterize …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

We studied the effects of cholinergic agonists on slow delayed-rectifier K current(lK) in
isolated cells from the sino-atrial node (SAN) region of guinea pig heart, using patch-clamp …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

The electrophysiological actions of quinacainol were investigated on sodium (INa), transient
outward (ito) and sustained‐outward plateau (iKsus) potassium currents in rat isolated …

A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization.
In these experiments, the time-dependent effects of quinidine on the delayed rectifier …

We examined the effects of quinidine on a slow delayed rectifier K current induced by a
human IsK cDNA (hlsK) in Xenopus oocytes. The apparent blocking potency of quinidine …