Traumatic brain injury (TBI) is a major cause of preventable death and morbidity in young
adults. This complex condition is characterized by a significant blood–brain barrier leakage …

Oxidative stress plays a significant role in secondary damage after severe traumatic brain
injury (TBI); and melatonin exhibits both direct and indirect antioxidant effects. Melatonin …

Oxidative stress (OS) and inflammation play a key role in the development of hypoxic–
ischemic (H–I) induced brain damage. Following H–I, rapid neuronal death occurs during …

This review covers the preclinical and clinical literature supporting the role of melatonin in
the management of brain injury-induced oxidative stress, neuroinflammation, and …

Building on the seminal work by Geoffrey Harris in the 1970s, the neuroendocrinology field,
having undergone spectacular growth, has endeavored to understand the mechanisms of …

Traumatic brain injury (TBI) represents a major public health concern. Although the majority
of individuals that suffer mild-moderate TBI recover relatively quickly, a substantial subset of …

The biochemical sequelae that follow traumatic brain injury (TBI) are numerous and affect
many different brain functions at different points of time as the secondary cascades progress …

Traumatic brain injury (TBI) is a leading cause of long-term disability and mortality in young
adults. The devastating effects of TBI on emotion regulation, executive functioning, and …

As many as 20–55% of patients with a history of traumatic brain injury (TBI) experience
chronic endocrine dysfunction, leading to impaired quality of life, impaired rehabilitation …

Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-
specific receptors on neuronal membranes in several brain regions. MEL's documented …