A hypothesis is proposed that reconciles the epidemiological observation of elevated
homocysteine in Alzheimer's disease (AD) with clinical features of the disease, particularly …

Elevated plasma homocysteine (tHcy) concentrations have been associated with an
increased risk of developing dementia and Alzheimer's disease (AD). It is not clear …

Dementia is a common and devastating public health problem, affecting an estimated
5±10% of individuals over the age of 65 [1]. Two pathologically distinct subtypes of …

Observational studies have consistently reported elevated plasma homocysteine as a risk
factor for Alzheimer's disease (AD). However, results from clinical trials of homocysteine …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Observational studies suggest that high homocysteine levels are a risk factor for brain
atrophy and Alzheimer disease, but intervention studies have been inconclusive. New …

Abstract Objectives Hyperhomocysteinemia in Alzheimer's disease (AD) is widely reported
and appears to worsen as the disease progresses. While active dietary intervention with …

BACKGROUND: Prospective cohort studies have not been consistent in showing an
association between serum homocysteine and dementia. OBJECTIVE: To conduct a meta …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

BACKGROUND: Plasma homocysteine is elevated in Alzheimer's disease, but little is known
regarding levels of related aminothiols in the disease. We therefore determined total plasma …