In the present study, we tested whether the ongoing differentiation of microglia in the
immature brain results in more robust microglial activation and pro-inflammatory responses …

The mechanisms of neuronal injury after hypoxia–ischemia (HI) are different in the immature
and the adult brain, but microglia activation has not been compared. The purpose of this …

We previously found increased microglial proliferation and pro-inflammatory cytokine
release in infant mice compared to juvenile mice after hypoxia–ischemia (HI). The aim of the …

Background: Perinatal asphyxia, leading to neonatal encephalopathy, is one of the leading
causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are …

Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …

Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …

Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes
mortality and long-term neurological impairments. Our previous study demonstrated …

Objective We examined regional specificity of microglial activation in the developing rat
brain for 72 hours after hypoxia-ischemia (HI) and the effect of acetylcholine receptor …

Immune cells display a high degree of phenotypic plasticity, which may facilitate their
participation in both the progression and resolution of injury-induced inflammation. The …

The inflammatory response following hypoxic-ischemia (HI) in the neonate is largely
unknown. Presently, the expression of microglial antigens and the β-amyloid precursor …