Background While pain is the hallmark of sickle cell disease (SCD), healthcare personnel
are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis …

Sickle cell disease (SCD) affects the red blood cells, which become sickle-shaped, leading
to their adhesion to vascular walls, impeding blood flow and causing the unpredictable …

Background and Objective: Sickle Cell Disease (SCD) is known to cause acute severe pain
episodes known as vaso-occlusive crisis (VOC) mainly treated with opioid analgesics. Since …

Limited evidence guides opioid dosing strategies for acute Sickle Cell (SCD) pain. We
compared two National Heart, Lung and Blood (NHBLI) recommended opioid dosing …

Objectives Pain management during a vaso‐occlusive crisis (VOC) for patients with sickle
cell disease (SCD) remains a major challenge and strongly depends on opioids. We …

Sickle cell disease (SCD) is a chronic condition characterized by multiple vaso-occlusive
complications, including acute pain crisis. The mainstay of treatment for patients presenting …

Methods This was a retrospective cohort study using Texas Medicaid medical and
prescription claims between September 2011 and August 2016. The index date was the first …

Vaso-occlusive pain crises are the hallmark of sickle cell disease (SCD) and the primary
reason for health care utilization. Both national and international guidelines recommend …

Guidelines for pain management in adult sickle cell patients with vaso-occlusive crises
suggest prompt, frequent administration of parenteral opioids. Neither the ability to …

Vaso-occlusive crisis (VOC) is the primary cause of hospitalization of patients with sickle-cell
disease. Treatment mainly consists of intravenous morphine, which has many dose-related …