Male infertility is a complex multifactorial disease affecting approximately 10% of couples
who want to have children. Some cases of infertility can be explained by genetic factors …

Background: Male infertility is a multifactorial disorder, which affects approximately 10% of
couples at childbearing age with substantial clinical and social impact. Genetic factors are …

SEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells.
SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental …

It is estimated that 10–15% of couples are infertile and male factors account for about half of
these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men …

Genetic mechanisms have been implicated as a cause of some cases of male infertility.
Recently, 10 novel genes involved in human spermatogenesis, including human SEPTIN12 …

Teratozoospermia is a condition related to poor morphologically normal sperm count below
the lower reference limit, which could hinder natural conception. Single nucleotide …

Infertility affects around 8%–12% of reproductive-aged couples and is a major health
concern. Both genetic and environmental factors influence male infertility. SEPTIN12 is a …

Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

Purpose To investigate the association between SEPTIN12 gene variants and the risk of
azoospermia caused by meiotic arrest. Methods Mutational analysis of the SEPTIN12 gene …

The SEPTIN12 gene has been associated with male infertility. Male Septin12+/− chimera
mice were infertile, supporting the prevailing view that SEPTIN12 haploinsufficiency causes …