Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is
expanded in patients with Huntington's disease (HD). We investigated the localization and a …

Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG
repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive …

Huntington's disease (HD) is caused by a genetic mutation that results in a polyglutamine
expansion in huntingtin. The time course of neuronal loss in the HD striatum and other …

Huntington's Disease is an adult-onset dominant heritable disorder characterized by
progressive psychiatric disruption, cognitive deficits, and loss of motor coordination. It is …

Although the gene responsible for Huntington's disease was discovered in 1993, the
pathogenic mechanisms by which mutant huntingtin causes neuronal dysfunction and death …

There are nine genetic neurodegenerative diseases caused by a similar genetic defect, a
CAG DNA triplet-repeat expansion in the disease gene's open reading frame resulting in a …

A pathological hallmark of polyglutamine diseases is the presence of inclusions or
aggregates of the expanded polyglutamine protein. Polyglutamine inclusions are present in …

Posttranslational modifications can have profound effects on the biological and biophysical
properties of proteins associated with misfolding and aggregation. However, their detection …

Abstract Huntington's disease (HD), is a genetic neurodegenerative disease characterized
by a DNA CAG triplet repeat expansion in the first exon of the disease gene, HD. CAG DNA …

Huntingtin expression was examined by Western blot and immunoprecipitation studies of
lymphoblastoid cell lines from Huntington's disease (HD) homozygotes, heterozygotes, and …