Previous investigations of the effects of GnRH on pituitary LH responses in normal men
required pharmacological doses of GnRH to avoid the confounding effects of endogenous …

The effects of increasing the frequency of pulsatile GnRH administration on LH and FSH
responsiveness were studied in five GnRH-deficient men who had achieved normal sex …

Although differences in plasma GnRH concentrations have been identified after iv and sc
injection of this peptide, differences in pituitary LH responses to iv and sc GnRH have not …

To examine the stimulus-secretion response of human pituitary gonadotrophs in vivo, we
applied a new multiple parameter deconvolution technique to analyze (1) exogenous GnRH …

We used the rat interstitial cell testosterone (RICT) bioassay to assess biological LH activity
secreted in response to endogenous and low dose exogenous GnRH pulses in normal men …

To assess its gonadotropin-inhibiting potency in man, three different doses of a GnRH
antagonist ([Ac-D2-Nal1, d4-Cl-Phe2, d3-Pal3, Arg5, d4-p-methoxybenzoyl-2-amino butyric …

Normal pituitary and gonadal function can be maintained with long term pulsatile GnRH
administration in men with idiopathic hypogonadotropic hypogonadism (IHH), and both …

We recently demonstrated that chronic daily administration of a superactive GnRH analog to
intact rats resulted in an initial stimulation of serum LH levels with a subsequent return of LH …

Healthy older men manifest concomitant hypoandrogenemia and attenuation of LH pulse
size. Because exogenous GnRH remains effective, a plausible intuition is that aging reduces …

Patients who have severe hypogonadotropic hypogonadism caused by presumed
hypothalamic disease often have a subnormal LH response to a bolus dose of …