PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for
coronavirus pathogenesis and is thus an attractive target for drug development. This …

Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I)
exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with
relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating …

Over 300 posttranslational modifications (PTMs) are known to modify the functions of
proteins by affecting processes ranging from activation, degradation, localization, secretion …

Poly (ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of
a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. PARP-7 is a …

The enzymes of the poly-ADP-ribose polymerase (PARP) superfamily control many relevant
cellular processes, but a precise understanding of their activities in different physiological or …

Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

Transcriptome analyses have recently identified PARP12, a member of a large family of ADP-
ribosyl transferases, as an interferon-induced gene (ISG), whose function remains …