The structural-functional regulation of enzymes by the administration of an external stimulus
such as light could create photo-switches that exhibit unique biotechnological applications …

Photochemical regulation provides a promising approach for controlling enzyme activity on
demand owing to its high spatiotemporal resolution. However, reversible regulation of the …

The design, synthesis, photoisomerism and biological testing of two peptide-based
photoswitchable inhibitors of α-chymotrypsin are presented. The use of a dipeptide …

The fine control of enzyme activity is essential for the regulation of many important cellular
and organismal functions. The light-regulation of proteins serves as an important method for …

Artificial photoenzymes offering non-natural reactivities present a promising synthetic
strategy, yet the use of red light remains challenging. In this issue of Chem, Gregory D …

Photopharmacology has attracted research attention as a new tool for achieving optical
control of biomolecules, following the methods of caged compounds and optogenetics. We …

α-Chymotrypsin (α-Chy) is modified with the nitrospiropyran active ester 1-(β-carboxyethyl-N-
hydroxysuccinimide ester)-3, 3-dimethyl6′-nitrospiro [indoline-2, 2′-2H-benzopyran](1) to …

Enzyme mimics emulate the catalytic activities of their natural counterparts. Light-responsive
enzyme mimics are an emerging branch of biomimetic chemistry where the catalytic …

A series of peptidomimetic trifluoromethylketones containing the photoisomerisable
azobenzene group have been synthesised, photoisomerised and assayed against the …

Ultrasensitivity is a ubiquitous emergent property of biochemical reaction networks. The
design and construction of synthetic reaction networks exhibiting ultrasensitivity has been …