Cell-autonomous defense mechanisms are potent strategies that protect individual cells
against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to …

Unlike broad-host Salmonella serovars, which cause self-limiting disease, Salmonella
enterica serovar Typhi can infect only humans causing typhoid fever, a life-threatening …

Intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and
survive within their eukaryotic hosts. In order to do this, bacterial pathogens need to avoid …

The ability to create and maintain a specialized organelle that supports bacterial replication
is an important virulence property for many intracellular pathogens. Living in a membrane …

Unlike other Salmonellae, the intracellular bacterial human pathogen Salmonella Typhi
exhibits strict host specificity. The molecular bases for this restriction are unknown. Here we …

Autophagy is an intracellular process that comprises degradation of damaged organelles,
protein aggregates and intracellular pathogens, having an important role in controlling the …

Macrophages provide a first line of defense against microorganisms, and while some
mechanisms to kill pathogens such as the oxidative burst are well described, others are still …

The food-borne bacterial pathogen Salmonella Typhimurium uses a type III protein secretion
system to deliver multiple proteins into host cells. These secreted effectors modulate the …

Members of the Rab guanosine triphosphatase (GTPase) family are key regulators of
membrane traffic. Here we examined the association of 48 Rabs with model phagosomes …

Intracellular bacterial pathogens deploy virulence factors termed effectors to inhibit
degradation by host cells and to establish intracellular niches where growth and …