Bacterial resistance to antibiotics makes previously manageable infections again disabling
and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of …

The widespread problem of bacterial resistance towards existing drugs and the paucity of
effective drugs for the treatment of bacterial infections have prompted the scientific …

The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

The disturbing increase in the number of bacterial pathogens that are resistant to multiple, or
sometimes all, current antibiotics highlights the desperate need to pursue the discovery and …

Combating anti-microbial resistance by developing alternative strategies is the need of the
hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an …

FtsZ is an essential bacterial protein abundantly studied as a novel and promising target for
antimicrobials. FtsZ is highly conserved among bacteria and mycobacteria, and it is crucial …

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It
is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of …

The bacterial cell division protein FtsZ is conserved in most bacteria and essential for
viability. There have been concerted efforts in developing inhibitors that target FtsZ as …

Essential cell division protein FtsZ is considered an attractive target in the search for
antibacterials with novel mechanisms of action to overcome the resistance problem. FtsZ …

The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial
drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have …