FOXP3-expressing T regulatory lymphocytes (Tregs) have been described as putative
mediators of immune tolerance, and thus facilitators of tumor growth. When found in …

FoxP3 is a marker for immunosuppressive CD25+ CD4+ regulatory T cells. These regulatory
T cells are thought to play a role in inducing immune tolerance to antigens and may be …

Background: Regulatory T cells (Tregs) are commonly identified by expression of the
transcription factor FOXP3 and are conventionally thought to promote cancer progression by …

Purpose: Forkhead box P3 (Foxp3) is known as the most specific marker for regulatory T
lymphocytes, which play an important role in immune tolerance to disturb antitumor …

Purpose To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T
cells (TR) in breast cancer patients with long-term follow-up. Patients and Methods FOXP3 …

Background: There is conflicting evidence regarding the prognostic value of cytotoxic T cell
infiltration in breast cancer. The aims of this study were to detect the expression levels and …

Abstract Background. Forkhead Box Protein 3 (FOXP3) is a marker for immunosuppressive
CD4+ CD25+ regulatory T cells (Tregs). We investigated whether there were significant …

The forkhead box protein 3 (FOXP3) transcription factor is highly expressed in tumor cells as
well as in regulatory T cells (Tregs). It plays a tumor-enhancing role in Tregs and suppresses …

FOXP3 is a transcription factor that is well known to be the hallmark of immune suppressive
T regulatory cells (Tregs), especially thymically derived natural Tregs. 1 Lack of FOXP3 …

Introduction The infiltration of FOXP3+ regulatory T cells into invasive tumors has been
reported to be associated with survival in a variety of cancers. The prognostic significance of …