Objective: To evaluate the activation of clotting systems in patients with sickle cell disease
(SCD) by measuring the plasma D‐dimer level and to determine the effect of low‐dose …

BACKGROUND: The pathophysiology of sickle cell disease (SCD) is complex, with
increasing evidence of a pronounced prothrombotic state. OBJECTIVE: We investigated …

The fibrin D-dimer degradation fragment is produced by plasmin degradation of cross-linked
fibrin. Elevated plasma D-dimer levels indicate increased plasmin degradation of cross …

Sickle cell disorders, such as Hb SS and Hb SC, are associated with a hypercoagulable
state that may contribute to the vaso‐occlusive episodes observed in the disorders. To what …

Although abnormalities in coagulation tests have been reported during vaso-occlusive
crises in patients with sickle cell disease, objective, readily performed laboratory tests that …

Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

Activation of coagulation is an important hallmark of sickle cell disease (SCD) and it is
believed that hypercoagulability plays a role to the disease pathophysiology. Studies have …

Objective: To determine the presence of ongoing thrombosis by measuring the DD dimer
levels in bone pain crises (BPCs) and in the steady state of patients with sickle cell disease …

Some studies have reported that systemic corticosteroids can be given to patients with sickle
cell disease (SCD) and a mild/moderate acute vaso-occlusive pain episode (VOE), which …

The most common cause for hospitalization and the hallmark of sickle cell disease (SCD) is
painful vaso-occlusive crisis (VOC). Several studies including our own have documented a …