Abstract The effects of disopyramide (1–30 μM) on the 4-aminopyridine sensitive transient
outward current (I to), on the rapid component of the delayed rectifier potassium current (I Kr) …

The blocking action of 4-aminopyridine (4-AP) on the transient outward K+ current (I TO) in
isolated rat ventricular myocytes was studied using the whole-cell configuration of the patch …

The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

In humans, proarrhythmia during therapy with action potential-prolonging drugs can be
associated with hypokalemia often provoked by concomitant administration of diuretic …

The inhibition of the adenosine triphosphate-sensitive K+ (KATP) current by disopyramide, a
class Ia antiarrhythmic drug, was studied using whole cell voltage clamp in cat ventricular …

The patch-clamp technique was used to study the relation between pinacidil and
intracellular ATP concentration [(ATP] i) on the activation of the outward K+ current in guinea …

The potassium currents in rat and guinea pig ventricular myocytes and mouse astrocytes
were studied using tedisamil, a novel antiarrhythmic agent. A 1 to 20 microM dosage of …

The 1, 4-dihydropyridine (DHP) Ca2+ antagonists and agonists can inhibit a time-and
voltage-dependent, but intracellular Ca (2+)-independent transient outward K+ current (It), in …

Electrophysiologic effects of disopyramide on cardiac membranes were studied using the
microelectrode technique applied to papillary muscles and the suction pipette whole-cel …

To determine the necessity of sodium channel fast inactivation for the block of sodium
current (l) by disopyramide, we studied the effects of disopyramide on l in guinea pig …