We examined the effect of continuous sc infusion of a GnRH agonist (Ag) and testosterone
(T) supplementation on spermatogenesis and the potential fertilizing capacity of sperm in 15 …

Three adult male rhesus monkeys were treated for 20 weeks with a gonadotropin-releasing
hormone (GnRH) agonist (Ag; Wy-40972; Wyeth Laboratories, Philadelphia, PA) using …

We studied the effects of administration of a GnRH antagonist combined with testosterone
(T) as an approach to male contraception as well as the role of intratesticular androgens in …

Constant infusion of gonadotropin-releasing hormone agonist (GnRH-A) in the rhesus
monkey leads to far greater suppression of spermatogenesis than its intermittent …

Treatment of 4 adult male rhesus monkeys for 8–12 months with 100–400 μg of a GnRH
antagonist/day by means of using osmotic minipumps led to suppressed serum …

Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …

Efforts to develop a hormonal contraceptive regimen for men have focused on administration
of testosterone (T), alone or together with other agents. Previous regimens have successfully …

Five adult male rhesus monkeys were continuously infused for 56 dayswith 25 μg/day of
GnRH agonist (Wy-40972; Ag) using an implanted osmotic pump. Bioassayable serum …

The effects of concomitant testosterone (T)-supplementation on gonadotropin-releasing
hormone (GnRH) antagonist-induced testicular regression in cynomolgus monkeys (M …

Although hormonal regimens provide effective, reversible contraception for women, no
effective hormonal contraceptive regimen has yet been developed for men. Testosterone …