Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats

R Kabirifar, F Safari, A Karimollah, A Moradi… - … & Pancreatic Diseases …, 2017 - Elsevier
Background Bile duct ligation (BDL) and subsequent cholestasis are correlated with
oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic …

Quercetin treatment ameliorates systemic oxidative stress in cirrhotic rats

EK Vieira, S Bona, FC Di Naso… - International …, 2011 - Wiley Online Library
Our aim was to investigate whether the antioxidant quercetin protects against liver injury and
ameliorates the systemic oxidative stress in rats with common bile duct ligation. Secondary …

Hepatoprotective effects of curcumin in rats after bile duct ligation via downregulation of Rac1 and NOX1

R Kabirifar, F Safari, A Karimollah, A Moradi… - Nutrition, 2017 - Elsevier
Objectives New evidence has proven the hepatoprotective activity of curcumin; however, its
underlying mechanisms remain to be elucidated. The aim of this study was to investigate the …

Beneficial effect of quercetin on cholestatic liver injury

SY Lin, YY Wang, WY Chen, YH Chuang… - The Journal of …, 2014 - Elsevier
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury,
cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress …

Quercetin mitigates hepatic insulin resistance in rats with bile duct ligation through modulation of the STAT3/SOCS3/IRS1 signaling pathway

A Khodarahmi, A Eshaghian, F Safari… - Journal of Food …, 2019 - Wiley Online Library
Insulin resistance (IR) and inflammatory mediators are correlated with hepatic fibrosis.
Quercetin is a bioflavonoid with well‐known antidiabetic and antifibrotic properties. Bile duct …

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

M Zhu, X Zhou, J Zhao - Experimental and therapeutic …, 2017 - spandidos-publications.com
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti‑
inflammatory activities, capable of treating a variety of diseases including …

Protective effect of quercetin on liver damage induced by biliary obstruction in rats

M Kanter - Journal of molecular histology, 2010 - Springer
The aim of this study was to evaluate the possible protective effects of quercetin (QE) against
cholestatic oxidative stress and liver damage in the common bile duct ligated rats. A total of …

The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction

W Peres, MJ Tuñón, PS Collado, S Herrmann… - Journal of …, 2000 - Elsevier
Background/Aims: Our aim was to investigate whether the antioxidant quercetin might
protect against liver injury in chronically biliary obstructed rats. Methods: Secondary biliary …

Comparison of antioxidant and anti‐inflammatory activity of quercetin, isoquercitrin and rutin against alcohol‐induced liver injury in HepG2 Cells

J Song, Y Kim, J Lee - The FASEB Journal, 2018 - Wiley Online Library
The dietary flavonoids and their glycosides are the most vital phytochemicals in diets and
are of great general interest due to their diverse bioactivities. The natural flavonoids almost …

Quercetin prevents oxidative stress in cirrhotic rats

PM Amália, MN Possa, MC Augusto… - Digestive diseases and …, 2007 - Springer
Our aim was to study the protective effect of quercitin on liver cirrhosis induced by carbon
tetrachloride (CCl 4) in rats and its relationship with liver morphology. Thirty male Wistar rats …