AIM: To assess whether blockade of the renin–angiotensin system (RAS), a recognized
strategy to prevent the progression of diabetic nephropathy, affects renal tissue oxygenation …

Aim Animal studies have suggested that acute hyperglycemia induces transient renal
hypoxia and kidney damage, yet this has not been tested in humans. Therefore, we …

PURPOSE: To evaluate the renal oxygenation in type 2 diabetes by blood oxygenation level
dependent magnetic resonance imaging (BOLD-MRI). MATERIALS AND METHODS: Forty …

Aims To compare levels of renal hypoxia measured by Blood Oxygen Level Dependent
(BOLD) magnetic resonance imaging (MRI) with measured transverse relaxation rate (R2*) …

Aims/hypothesis Pathophysiological abnormalities in early diabetic nephropathy are poorly
understood. We employed MRI to characterise renal perfusion, tissue oxygenation and …

Background Diabetic kidney disease (DKD) accounts for∼ 50% of end-stage kidney
disease. Renal hypoxia is suggested as a main driver in the pathophysiology underlying …

Imaging of the kidney using blood oxygen level dependent (BOLD) magnetic resonance
imaging (MRI) presents a major opportunity to examine differences in tissue oxygenation …

Background: The renin–angiotensin–aldosterone system (RAAS) and the sympathetic
nervous system are key factors in the pathophysiology of hypertension. Renal hypoxia is the …

Purpose: To evaluate the blood oxygen level‐dependent (BOLD) magnetic resonance
imaging (MRI) findings in kidneys of patients with diabetic nephropathy. Materials and …

Experimentally renal tissue hypoxia appears to play an important role in the pathogenesis of
chronic kidney disease (CKD) and arterial hypertension (AHT). In this study we measured …