Macromolecular crowding conditions occurring inside the cell nucleus were reproduced experimentally with solutions of mononucleosome core particles to study their …
We present a phase diagram of the nucleosome core particle (NCP) as a function of the monovalent salt concentration and applied osmotic pressure. Above a critical pressure …
A Bertin, S Mangenot, M Renouard, D Durand… - Biophysical journal, 2007 - cell.com
The degree of compaction of the eukaryotic chromatin in vivo and in vitro is highly sensitive to the ionic environment. We address the question of the effect of multivalent ions on the …
The nucleosome core particle (NCP) is the basic building block of chromatin. Nucleosome- nucleosome interactions are instrumental in chromatin compaction, and understanding NCP …
J Bednar, RA Horowitz, SA Grigoryev… - Proceedings of the …, 1998 - National Acad Sciences
The compaction level of arrays of nucleosomes may be understood in terms of the balance between the self-repulsion of DNA (principally linker DNA) and countering factors including …
M Eltsov, D Grewe, N Lemercier… - Nucleic acids …, 2018 - academic.oup.com
In Eukaryotes, DNA is wound around the histone octamer forming the basic chromatin unit, the nucleosome. Atomic structures have been obtained from crystallography and single …
Nucleosome core particles correspond to the structural units of eukaryotic chromatin. They are charged colloids, 101 Å in diameter and 55 Å in length, formed by the coiling of a …
F Mühlbacher, H Schiessel, C Holm - … E—Statistical, Nonlinear, and Soft Matter …, 2006 - APS
We study a possible electrostatic mechanism underlying the compaction of DNA inside the nuclei of eucaryotes: the tail-bridging effect between nucleosomes, the fundamental DNA …
AG Cherstvy, R Everaers - Journal of Physics: Condensed Matter, 2006 - iopscience.iop.org
We propose an idea how the helical pattern of charges on the surface of DNA can affect electrostatic interactions of nucleosome core particles in their columnar and crystalline …