Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

M Heilig, B Söderpalm, JA Engel, E Widerlöv - Psychopharmacology, 1989 - Springer
Abstract Effects of intracerebroventircular (ICV), neuropeptide Y (NPY)(0.2–5.0 nmol) and its
C-terminal 13–36 amino acid (AA) fragment (0.4–2.0 nmol) have been examined with …

Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures

P Broqua, JG Wettstein, MN Rocher… - Behavioural …, 1995 - journals.lww.com
Evidence from animal studies has led to the proposal that neuropeptide Y (NPY) has
anxiolytic-like effects in rats after intracerebroventricular (icv) administration. The purpose of …

Neuropeptide Y produces anxiety via Y2-type receptors

M Nakajima, A Inui, A Asakawa, K Momose, N Ueno… - Peptides, 1998 - Elsevier
Nakajima, M., A. Inui, A. Asakawa, K. Momose, N. Ueno, A. Teranishi, S. Baba and M.
Kasuga. Neuropeptide Y produces anxiety via Y2-type receptors. Peptides 19 (2) 359–363 …

Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects

M Heilig, S McLeod, M Brot, SC Heinrichs… - …, 1993 - nature.com
Evidence from animal and human studies suggests that neuropeptide Y (NPY) may be a
potent endogenous anxiolytic. The anatomic structures mediating this action of the peptide …

Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effects of electroconvulsive stimuli

PA Jiménez-Vasquez, DH Overstreet… - Journal of psychiatric …, 2000 - Elsevier
Human and animal studies suggest that neuropeptide Y (NPY), a peptide co-localized and
co-released with classical neurotransmitters, is involved in the pathogenesis of affective …

Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with α-adrenoceptors

M Heilig, C Wahlestedt, E Widerlöv - European journal of pharmacology, 1988 - Elsevier
The receptor mechanisms mediating the neuropeptide Y (NPY)-induced suppression of
behavioural activity have been examined in the rat. The interaction of NPY with central …

Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13–36 microinjected into vicinity of locus coeruleus in rats

A Kask, L Rägo, J Harro - Brain research, 1998 - Elsevier
Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34] NPY (10
pmol) and Y2 agonist NPY13–36 (100 pmol) were administered unilaterally into the region …

Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain

M Heilig, C Wahlestedt, R Ekman, E Widerlöv - European journal of …, 1988 - Elsevier
Rats were given imipramine or zimeldine orally for three weeks and the brain levels of
neuropeptide Y-like immunoreactivity (NPY-LI) were measured. The concentration of NPY-LI …

The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

A Kask, J Harro, S von Hörsten, JP Redrobe… - Neuroscience & …, 2002 - Elsevier
This review aims to give a brief overview of NPY receptor distribution and physiology in the
brain and summarizes series of studies, test by test and region by region, aimed at …

[PDF][PDF] Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem.

L Grundemar, C Wahlestedt, DJ Reis - Journal of Pharmacology and …, 1991 - Citeseer
Microinjection of neuropeptide V (NPY) into the nucleus tractus solitarius(NTS) induces an
initial and reversible fall in arterial pressure (AP) and heart rate (HA), along with a delayed …