Protective Effect of Dietary Supplementation with L- Arginine and L- Carnitine on Hypoxia/Reoxygenation-Induced Necrotizing Enterocolitis in Young Mice

M Akisu, D Ozmen, M Baka, S Habif, M Yalaz… - Neonatology, 2002 - karger.com
Oxygen-derived free radicals are important components of gastrointestinal injury in
necrotizing enterocolitis (NEC). In the present investigation, we examined the protective …

The Role of Dietary Supplementation with L-Glutamine in Inflammatory Mediator Release and Intestinal Injury in Hypoxia/Reoxygenation-Induced Experimental …

M Akisu, M Baka, A Huseyinov… - Annals of Nutrition and …, 2003 - karger.com
Abstract Background/Aims: Necrotizing enterocolitis (NEC) is a multifactorial syndrome in
the neonate. Enteral feeding practices are an important component of gastrointestinal injury …

Effects of L‐arginine and L‐carnitine in hypoxia/reoxygenation‐induced intestinal injury

C Kabaroglu, M Akisu, S Habif, I Mutaf… - Pediatrics …, 2005 - Wiley Online Library
Background: This study was designed to show the role of oxidative stress, nitric oxide and
glutathione‐related antioxidant enzymes in hypoxia/reoxygenation (H/R)‐induced intestinal …

Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

R Ozdemir, S Yurttutan, FN Sarı, B Uysal… - Journal of Pediatric …, 2012 - Elsevier
BACKGROUND/PURPOSE: Hypoxia and ischemia appear to play an important role in the
pathogenesis of necrotizing enterocolitis (NEC), which may be related to oxygen-derived …

Nitric oxide levels in the intestines of mice submitted to ischemia and reperfusion: L-arginine effects

A Cintra, JL Martins, FRS Patrício, EMS Higa… - Transplantation …, 2008 - Elsevier
OBJECTIVE: Usualy an experimental necrotizing enterocolitis experimental model, we
Investigated nitric oxide levels in intestinal tissues of newborn mice with or without l-arginine …

Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing …

O Ergün, G Ergün, G Öktem, N Selvi, H Doğan… - Journal of pediatric …, 2007 - Elsevier
BACKGROUND/PURPOSE: The release of various enzymes including inducible nitric oxide
synthase (iNOS) leads to enterocyte apoptosis through free nitrogen radicals, which in turn …

Pentoxifylline does not prevent hypoxia/reoxygenation-induced necrotizing enterocolitis: An experimental study

D Erdener, F Bakirtas, M Alkanat, I Mutaf, S Habif… - Neonatology, 2004 - karger.com
Abstract Hypoxia/reoxygenation (H/R)-induced intestinal injury plays a significant role in the
development of necrotizing enterocolitis (NEC). We experimentally explored the effect of …

Effect of NG-Nitro-L-Arginine Methyl Ester on Intestinal Permeability following Intestinal Ischemia-Reperfusion Injury in a Rat Model

CC Luo, HM Chen, CH Chiu, JN Lin, JC Chen - Neonatology, 2001 - karger.com
Subclinical intestinal ischemia-reperfusion injury (IRI) causes an increase in mucosal
permeability and may represent an early event in the pathogenesis of necrotizing …

Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E

H Okur, M Küçükaydin, K Köse, O Kontaş… - Journal of pediatric …, 1995 - Elsevier
The authors developed an experimental model of necrotizing enterocolitis (NEC) by hypoxia-
reoxygenation, and determined the content of malondialdehyde levels as an index of lipid …

Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats

A Guven, G Gundogdu, S Vurucu, B Uysal… - Journal of pediatric …, 2009 - Elsevier
PURPOSE: Necrotizing enterocolitis (NEC) remains a major cause of morbidity and death in
neonates. Evidence suggests that an imbalance between activated proinflammatory …