Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

Background. Tissue properties may contribute to intrinsic calcification of bioprosthetic heart
valves. Phospholipids have been proposed as potential nucleation sites for calcification …

Surgical replacement with artificial devices has revolutionised the care of patients with
severe valvular diseases. Mechanical valves are very durable, but require long-term …

Bioprosthetic heart valves are widely used because of their low risk of thromboembolic
complications. The major limitation to the longterm success of these prostheses is caused by …

Calcification of bioprostheses used for heart valve replacement is a serious problem, since it
causes bioprosthetic dysfunction. In vivo, bioprostheses are subjected to large mechanical …

The earliest description of calcific aortic stenosis is attributed to the French physician Lazare
Rivière who, in 1663, reported the necropsy findings from a patient with palpitations …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Deposition of calcium-containing apatite mineral occurs widely in association with
cardiovascular and noncardiovascular medical devices and biomaterials, is the leading …

Methods A total of 60 explanted porcine bioprosthetic valves was tested mechanically, and
15 explanted valves were examined grossly and histologically. Circumferentially and …