Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …

The related transcriptional co-factors YAP (Yes-associated protein) and TAZ (transcriptional
co-activator with PDZ-binding motif) have been proposed to either promote or inhibit …

Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both
the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus …

The Runx2 transcription factor is required for commitment of mesenchymal cells to bone
lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to …

We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2
expression levels and transcriptional activity is important for bone morphogenetic protein …

The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation
and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor …

RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and
p38 MAP kinase‐mediated phosphorylation. However, the specific contribution of each …

Runx2 is an essential transcription factor for skeletal mineralization because it stimulates
osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy …

The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate
decisions controlled by a hierarchy of transcription factors. These include RUNX2, Osterix …