Viral infection initiates a series of signaling cascades that activate the transcription factors
nuclear factor kappa B and interferon regulatory factor 3, which collaborate to induce …

Viral infection triggers a series of signaling cascades, which converge to activate the
transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) …

Ubiquitination and deubiquitination have emerged as critical regulatory processes in the
virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a …

Ubiquitylation is an important mechanism for regulating innate immune responses to viral
infections. Attachment of lysine 63 (Lys63)–linked ubiquitin chains to the RNA sensor …

Abstract Lysine 63 (K63)-linked ubiquitination of RIG-I plays a critical role in the activation of
type I interferon pathway, yet the molecular mechanism responsible for its deubiquitination is …

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5
(MDA5) are essential intracellular detectors of viral RNA. They contribute to the type I …

Abstract Ubiquitin specific protease 14 (USP14) is a regulator of protein deubiquitination
and proteasome activation, and has been implicated in negative regulation of type I IFN …

Retinoic acid‐inducible gene I (RIG‐I) is a critical RNA virus sensor that initiates antiviral
immune response through K63‐linked ubiquitination. In this study, we demonstrated USP14 …

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the
molecular mechanism that negatively regulates this critical step is poorly understood. Here …

Upon detection of viral RNA, retinoic acid-inducible gene I (RIG-I) undergoes TRIM25-
mediated K63-linked ubiquitination, leading to type I interferon (IFN) production. In this …