Homocysteine concentrations in the cognitive progression of Alzheimer's disease

N Farina, F Jernerén, C Turner, K Hart, N Tabet - Experimental Gerontology, 2017 - Elsevier
Abstract Objectives Hyperhomocysteinemia in Alzheimer's disease (AD) is widely reported
and appears to worsen as the disease progresses. While active dietary intervention with …

Hyperhomocysteinemia and Alzheimer's disease: A systematic review

F Van Dam, WA Van Gool - Archives of gerontology and geriatrics, 2009 - Elsevier
Hyperhomocysteinemia (HHcy) is supposed to be one of the modifiable risk factors that, if
treated, may delay the onset of Alzheimer's disease (AD). The relation between serum …

A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease

PS Aisen, S Egelko, H Andrews, R Diaz-Arrastia… - The American journal of …, 2003 - Elsevier
OBJECTIVE Authors determined the impact of high-dose vitamin supplements on plasma
homocysteine levels in patients with Alzheimer disease (AD). METHODS Authors used an …

Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials

AH Ford, OP Almeida - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Elevated total plasma homocysteine has been linked to the development of cognitive
impairment and dementia in later life and this can be reliably lowered by the daily …

Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet

JM Zhuo, D Praticò - Experimental gerontology, 2010 - Elsevier
Epidemiological and clinical studies indicate that elevated circulating level of homocysteine
(Hcy) is a risk factor for developing Alzheimer's disease (AD). Dietary deficiency of folate …

Blood and CSF homocysteine levels in Alzheimer's disease: A meta-analysis and meta-regression of case–control studies

L Zhang, X Xie, Y Sun, F Zhou - Neuropsychiatric Disease and …, 2022 - Taylor & Francis
Objective Hyperhomocysteinemia (HHcy), as an important risk factor for Alzheimer's disease
(AD), would aggravate cognitive dysfunction. This study aimed to investigate whether and to …

Homocysteine and cognitive function in elderly people

A Garcia, K Zanibbi - Cmaj, 2004 - Can Med Assoc
DEMENTIA IS HIGHLY PREVALENT AMONG ELDERLY PEOPLE, and projections show
that the number of people affected might triple over the next 50 years, mainly because of a …

Homocysteine as a predictor of cognitive decline in Alzheimer's disease

A Oulhaj, H Refsum, H Beaumont… - … journal of geriatric …, 2010 - Wiley Online Library
Objective Moderately elevated levels of plasma total homocysteine are associated with an
increased risk of developing Alzheimer's disease. We have tested whether baseline …

Cognitive and clinical outcomes of homocysteine‐lowering B‐vitamin treatment in mild cognitive impairment: a randomized controlled trial

CA De Jager, A Oulhaj, R Jacoby… - … journal of geriatric …, 2012 - Wiley Online Library
Background Homocysteine is a risk factor for Alzheimer's disease. In the first report on the
VITACOG trial, we showed that homocysteine‐lowering treatment with B vitamins slows the …

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial

AD Smith, SM Smith, CA De Jager, P Whitbread… - PloS one, 2010 - journals.plos.org
Background An increased rate of brain atrophy is often observed in older subjects, in
particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain …