Strategies to improve/eliminate the limitations in shotgun lipidomics

C Hu, Q Duan, X Han - Proteomics, 2020 - Wiley Online Library
Direct infusion‐based shotgun lipidomics is one of the most powerful and useful tools in
comprehensive analysis of lipid species from lipid extracts of various biological samples with …

Novel advances in shotgun lipidomics for biology and medicine

M Wang, C Wang, RH Han, X Han - Progress in lipid research, 2016 - Elsevier
The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

Comprehensive evaluation of a quantitative shotgun lipidomics platform for mammalian sample analysis on a high-resolution mass spectrometer

IØ Nielsen, A Vidas Olsen… - Journal of the …, 2020 - ACS Publications
Shotgun lipidomics is a powerful tool that enables simultaneous and fast quantification of
diverse lipid classes through mass spectrometry based analyses of directly infused crude …

Chemical derivatization and ultrahigh resolution and accurate mass spectrometry strategies for “shotgun” lipidome analysis

E Ryan, GE Reid - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus Lipids play critical structural and functional roles in the regulation of cellular
homeostasis, and it is increasingly recognized that the disruption of lipid metabolism or …

Multi‐dimensional mass spectrometry‐based shotgun lipidomics and novel strategies for lipidomic analyses

X Han, K Yang, RW Gross - Mass spectrometry reviews, 2012 - Wiley Online Library
Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …

Shotgun lipidomics by sequential precursor ion fragmentation on a hybrid quadrupole time-of-flight mass spectrometer

B Simons, D Kauhanen, T Sylvänne, K Tarasov… - Metabolites, 2012 - mdpi.com
Shotgun lipidomics has evolved into a myriad of multi-dimensional strategies for molecular
lipid characterization, including bioinformatics tools for mass spectrum interpretation and …

On mass ambiguities in high-resolution shotgun lipidomics

C Bielow, G Mastrobuoni, M Orioli, S Kempa - Analytical chemistry, 2017 - ACS Publications
Mass-spectrometry-based lipidomics aims to identify as many lipid species as possible from
complex biological samples. Due to the large combinatorial search space, unambiguous …

Analytical challenges of shotgun lipidomics at different resolution of measurements

J Wang, X Han - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
The essence of shotgun lipidomics is to maintain consistency of the chemical environment of
lipid samples during mass spectrometry acquisition. This strategy is suitable for large-scale …

Mass spectrometry-based shotgun lipidomics–a critical review from the technical point of view

FF Hsu - Analytical and bioanalytical chemistry, 2018 - Springer
Over the past decade, mass spectrometry (MS)-based “shotgun lipidomics” has emerged as
a powerful tool for quantitative and qualitative analysis of the complex lipids in the biological …

Advances in mass spectrometry for lipidomics

SJ Blanksby, TW Mitchell - Annual Review of Analytical …, 2010 - annualreviews.org
Recent expansion in research in the field of lipidomics has been driven by the development
of new mass spectrometric tools and protocols for the identification and quantification of …