Melatonin‐induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late‐phase activation of NF‐κB and AP‐1
Traumatic brain injury (TBI) is followed by massive production of reactive oxygen species
(ROS), which mediate secondary cellular damage. Low molecular weight antioxidants …
(ROS), which mediate secondary cellular damage. Low molecular weight antioxidants …
Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway
J Wang, C Jiang, K Zhang, X Lan, X Chen… - Free radical biology and …, 2019 - Elsevier
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin,
a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant …
a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant …
Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential …
K Ding, H Wang, J Xu, T Li, L Zhang, Y Ding… - Free Radical Biology …, 2014 - Elsevier
The goal of this study was to evaluate the potential involvement of melatonin in the activation
of the nuclear factor erythroid 2-related factor 2 and antioxidant-responsive element (Nrf2 …
of the nuclear factor erythroid 2-related factor 2 and antioxidant-responsive element (Nrf2 …
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression
Melatonin has been widely studied as a protective agent against oxidative stress. However,
the molecular mechanisms underlying neuroprotection in neurodegeneration and ischemic …
the molecular mechanisms underlying neuroprotection in neurodegeneration and ischemic …
Melatonin as a potential regulator of oxidative stress, and neuroinflammation: mechanisms and implications for the management of brain injury-induced …
This review covers the preclinical and clinical literature supporting the role of melatonin in
the management of brain injury-induced oxidative stress, neuroinflammation, and …
the management of brain injury-induced oxidative stress, neuroinflammation, and …
Melatonin attenuates brain contusion‐induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of …
MC Tsai, WJ Chen, MS Tsai, CH Ching… - Journal of pineal …, 2011 - Wiley Online Library
The induction of oxidative stress and inflammation has been closely linked in traumatic brain
injury (TBI). Transcriptional factors of signal transducers and activators of transcription …
injury (TBI). Transcriptional factors of signal transducers and activators of transcription …
Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice
CM Chern, JF Liao, YH Wang, YC Shen - Free Radical Biology and …, 2012 - Elsevier
Melatonin has many protective effects against ischemic stroke, but the underlying
neuroprotective mechanisms are not fully understood. Our aim was to explore the …
neuroprotective mechanisms are not fully understood. Our aim was to explore the …
Protective effect of melatonin in a model of traumatic brain injury in mice
C Mésenge, I Margaill, C Verrecchia… - Journal of pineal …, 1998 - Wiley Online Library
The pineal hormone melatonin has recently been shown to exert neuroprotective activity in a
variety of experimental neuropathologies in which free radicals are involved. This …
variety of experimental neuropathologies in which free radicals are involved. This …
Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats
P Thangwong, P Jearjaroen, P Govitrapong… - Biochemical …, 2022 - Elsevier
Chronic cerebral hypoperfusion (CCH) is the most common cause of cognitive impairment,
which is commonly found in Alzheimer's disease (AD) and vascular dementia (VaD) …
which is commonly found in Alzheimer's disease (AD) and vascular dementia (VaD) …
The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial
Z Zhao, C Lu, T Li, W Wang, W Ye… - Journal of Pineal …, 2018 - Wiley Online Library
Carotid endarterectomy (CEA) is the treatment of choice for carotid stenosis. Some patients
develop ischemia and reperfusion (I/R) injury after CEA. This study was designed to …
develop ischemia and reperfusion (I/R) injury after CEA. This study was designed to …