The nucleus is a highly structured organelle with many chromatin and protein compartments
that partition the genome into regulatory domains. One such a compartment within the …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

It is now well accepted that defined architectural compartments within the cell nucleus can
regulate the transcriptional activity of chromosomal domains within their vicinity. However, it …

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that
lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the …

The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining
the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses …

The genome is dynamically organized in the nuclear space in a manner that reflects and
influences nuclear functions. Developmental processes that govern the formation and …

In metazoan cells, the heterochromatin is generally localized at the nuclear periphery,
whereas active genes are preferentially found in the nuclear interior. In the present paper …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

During the past three decades, the study of nuclear and chromatin organization has become
of great interest. The organization and dynamics of chromatin are directly responsible for …

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to
promote efficient gene expression and to faithfully maintain silencing of heterochromatin …