Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin
gene HBB leading to polymerization of red blood cells causing damage to cell membranes …

Sickle cell disease (SCD) is a hereditary disorder that leads to the production of an
abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Sickle cell disease (SCD) is a hematologic disorder caused by a well‐characterized point
mutation in the β‐globin gene. Abnormal polymerization of hemoglobin tetramers results in …

Sickle cell disease (SCD) is an autosomal recessive disease in which homozygosity for a
single point mutation in the gene encoding the β-globin chain produces hemoglobin S …

Sickle cell disease (SCD) is an hereditary disorder characterized by the production of an
abnormal hemoglobin called hemoglobin S (HbS). HbS may polymerize in deoxygenated …

Sickle cell disease (SCD) is caused by a mutation in both beta globin genes, resulting in
chronic hemolysis and multiorgan disease that ultimately leads to premature death …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide. It is a multisystem disease that causes considerable patient morbidity. Despite …

Introduction: Sickle cell disease (SCD) is a devastating monogenic disorder that presents as
a multisystem illness and affects approximately 100,000 individuals in the United States …

Introduction In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are
characteristically deformed and inflexible. Often breaking down in the circulation, they …