Abstract Significance: Hydrogen peroxide (H2O2) is known to act as a messenger in signal
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …

Abstract Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H 2 O 2
detoxifiers, and more recently as H 2 O 2 sensors, intermediates in redox-signaling …

A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …

Reversible oxidation of thiol proteins is an important cell signalling mechanism. In many
cases, this involves generation or exposure of the cells to H2O2, and oxidation of proteins …

Evidence has accumulated showing that hydrogen peroxide (H 2 O 2) acts as a signaling
molecule via oxidation of critical cysteine residues on target proteins. The reaction of H 2 O 2 …

Protein–protein associations, ie formation of permanent or transient protein complexes, are
essential for protein functionality and regulation within the cellular context. Peroxiredoxins …

Abstract Significance: Hydrogen peroxide (H2O2) is produced on stimulation of many cell
surface receptors and serves as an intracellular messenger in the regulation of diverse …

Peroxiredoxins are highly conserved and abundant peroxidases. Although the thioredoxin
peroxidase activity of peroxiredoxin (Prx) is important to maintain low levels of endogenous …

Mammalian cells have a well‐defined set of antioxidant enzymes, which includes
superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins …

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …