It is well established that endothelin‐1 (ET‐1) plays a role in differentiation and proliferation
in a variety of cells such as fibroblasts and human melanoma cells via a receptor‐mediated …

Cell migration is mediated by ion channels and transporters, and plays crucial roles in a
variety of physiological and pathological processes. Previously, our studies have shown that …

Abstract Aims: Endothelin‐1 (ET‐1) promotes endothelial cell growth. Endothelial cell
proliferation involves the activation of Ca2+‐activated K+ channels. In this study, we …

Melanoma cells are transformed melanocytes of neural crest origin. K+ channel blockers
have been reported to inhibit melanoma cell proliferation. We used whole-cell recording to …

Ca2+ channels activated by endothelin-1 (ET-1) in C6 glioma cells (C6 cells) were
characterized using whole-cell patch-clamps and by monitoring the intracellular free Ca2+ …

Endothelin-1 (ET-1) has been shown to require Ca2+ influx for activation of vascular smooth
muscle in vivo, but in vitro models show that ET-1 mobilizes intracellular Ca2+ and is …

Previously, we showed that migration of transformed renal epithelial cells (MDCK-F cells) is
a K+ channel-dependent process [J Clin Invest 1994; 93: 1631]. In order to determine …

K+ channels, membrane voltage, and intracellular free Ca 2+ are involved in regulating
proliferation in a human melanoma cell line (SK MEL 28). Using patch-clamp techniques, we …

Abstract Endothelin-1 (ET) elevates intracellular calcium ([Ca 2+] i) and increased [Ca 2+] i
has been associated with K+ efflux. Therefore, we investigated ET stimulation of K+ efflux in …

Aim To investigate the role of endothelin-1 (ET-1) in the physiological and
pathophysiological regulating mechanisms of voltage-gated K+ current (IKV) inhibition in rat …