Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver

UC Nygaard, Å Vege, T Rognum, K Grob… - Food and Chemical …, 2019 - Elsevier
Humans are daily exposed to mineral oil saturated hydrocarbons (MOSH) from the diet. We
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats‐specificity of different subclasses of a broad mixture relevant for human dietary exposures

JP Cravedi, K Grob, UC Nygaard… - EFSA supporting …, 2017 - Wiley Online Library
The purpose of this study was to investigate the fate and effects of mineral oil saturated
hydrocarbons (MOSH) in female Fischer 344 rats. Animals were fed control diet or diet …

Mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats; accumulation of wax components; implications for risk assessment

L Barp, M Biedermann, K Grob, F Blas-Y-Estrada… - Science of the Total …, 2017 - Elsevier
Female Fischer 344 rats were exposed to three MOSH mixtures: oils largely below and
above C 25 (S-C25 and L-C25) and a 1: 1 mixture of L-C25 with a wax; doses of 400, 1000 …

Accumulation of mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats: comparison with human data and consequences for risk assessment

L Barp, M Biedermann, K Grob, F Blas-Y-Estrada… - Science of the Total …, 2017 - Elsevier
Female Fischer 344 rats were orally exposed to a mixture of mineral oil saturated
hydrocarbons (MOSH) of broad molecular mass range at doses of 40, 400 and 4000 mg/kg …

Scientific opinion on mineral oil hydrocarbons in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2012 - Wiley Online Library
Consumers are exposed to a range of mineral oil hydrocarbons (MOH) via food. Mineral oil
saturated hydrocarbons (MOSH) consist of linear and branched alkanes, and alkyl …

Update of the risk assessment of mineral oil hydrocarbons in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2023 - Wiley Online Library
Mineral oil hydrocarbons (MOH) are composed of saturated hydrocarbons (MOSH) and
aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their …

A study of the toxicity of five mineral hydrocarbon waxes and oils in the F344 rat, with histological examination and tissue-specific chemical characterisation of …

MJ Scotter, L Castle, RC Massey, PG Brantom… - Food and chemical …, 2003 - Elsevier
Five food-grade mineral hydrocarbon (MHC) materials; a low melting point wax (LMPW), a
synthetic wax (C80W) and three white oils (N15H, N70H and P70H) were administered …

Mineral oil in human tissues, Part I: Concentrations and molecular mass distributions

L Barp, C Kornauth, T Wuerger, M Rudas… - Food and Chemical …, 2014 - Elsevier
Abstract Of 37 subjects aged 25–91 y (mean 67 y), mineral oil hydrocarbons were measured
in subcutaneous abdominal fat tissue, mesenteric lymph nodes (MLN), spleen, liver and …

Mineral oil in food, cosmetic products, and in products regulated by other legislations

R Pirow, A Blume, N Hellwig, M Herzler… - Critical reviews in …, 2019 - Taylor & Francis
For a few years, mineral oils and their potential adverse health effects have been a constant
issue of concern in many regulatory areas such as food, cosmetics, other consumer …

Granulomas in the livers of humans and Fischer rats associated with the ingestion of mineral hydrocarbons: a comparison

KA Fleming, H Zimmerman, P Shubik - Regulatory Toxicology and …, 1998 - Elsevier
Ninety-day feeding studies were conducted in Fischer 344 rats using a series of highly
refined mineral hydrocarbons which included mineral oils and waxes representative of those …