Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis
but also constitutes a mechanism of neurodegeneration. It is unclear how autophagy of …

At the synapse, proteins are reused several times during neuronal activity, causing a decline
in protein function over time. Although emerging evidence supports a role of autophagy in …

Lysosome membrane recycling occurs at the end of the autophagic pathway and requires
proteins that are mostly encoded by genes mutated in neurodegenerative diseases …

Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral
sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar …

J. Neurochem.(2011) 10.1111/j. 1471‐4159.2011. 07521. x Abstract HspB8, a small heat‐
shock protein implicated in autophagy, is mutated in patients with distal hereditary motor …

Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis
(fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) …

ABSTRACT A major cellular catabolic pathway in neurons is macroautophagy/autophagy,
through which misfolded or aggregation-prone proteins are sequestered into …

Small GTPases of the Rab family not only regulate target recognition in membrane traffic but
also control other cellular functions such as cytoskeletal transport and autophagy. Here we …

Autophagy is a cellular digestion process that contributes to cellular homeostasis and
adaptation by the elimination of proteins and damaged organelles. Evidence suggests that …

The molecular mechanism underlying the selective vulnerability of certain neuronal
populations associated with neurodegenerative diseases remains poorly understood. Basal …